Iron withholding: A defense against viral infections
Identifieur interne : 002A37 ( Main/Exploration ); précédent : 002A36; suivant : 002A38Iron withholding: A defense against viral infections
Auteurs : E. D. Weinberg [États-Unis]Source :
- Biometals [ 0966-0844 ] ; 1996-10-01.
English descriptors
- KwdEn :
- Teeft :
- Alveolar macrophages, Animal models, Cemeroglu ozsoylu, Chronic hepatitis, Clinical phase, Daily dose, Defense system, Different study, Excessive iron, Ferritin, Hepatic, Hepatic iron content, Hepatitis, Herpes virus, Host cells, Human immunodeficiency virus type, Indiana university, Infection, Iron content, Iron loading, Iron metabolism, Iron reduction therapy, Iron values, Iron withholding, Iron withholding defense system, Japanese encephalitis virus, Karupiah harris, Kupffer cells, Macrophage, Mild infections, Nitric, Nitric oxide, Oxidative stress, Oxide, Replication, Serum ferritin, Serum iron, Serum iron levels, Similar study, Smoker, Surface antigen, Thalassemic patients, Transcriptase activity, Transferrin, Transferrin iron saturation, Transfusion, Viral, Viral infections, Viral replication, Weinberg, Weinberg weinberg.
Abstract
Abstract: A variety of laboratory and clinical investigations during the past 15 years have observed that one of the dangers of excessive iron is its ability to favor animal viral infections. The metal is essential for host cell synthesis of virions and can also impair defense cell function and increase oxidative stress. In both animal models and humans, viral infections cause upregulation of the iron withholding defense system. Factors that suppress the system enhance viral progression; factors that strengthen the system augment host defense. Procedures designed to reinforce the system are being developed and tested; some of these may become useful adjuncts in prevention and management of viral diseases.
Url:
DOI: 10.1007/BF00140609
Affiliations:
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Le document en format XML
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Weinberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology and Program in Medical Sciences, Indiana University, Bloomington, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Biometals</title><title level="j" type="abbrev">Biometals</title><idno type="ISSN">0966-0844</idno><idno type="eISSN">1572-8773</idno><imprint><publisher>Kluwer Academic Publishers</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="1996-10-01">1996-10-01</date><biblScope unit="volume">9</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="393">393</biblScope><biblScope unit="page" to="399">399</biblScope></imprint><idno type="ISSN">0966-0844</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0966-0844</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>iron</term><term>iron withholding defense</term><term>viral infections</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Alveolar macrophages</term><term>Animal models</term><term>Cemeroglu ozsoylu</term><term>Chronic hepatitis</term><term>Clinical phase</term><term>Daily dose</term><term>Defense system</term><term>Different study</term><term>Excessive iron</term><term>Ferritin</term><term>Hepatic</term><term>Hepatic iron content</term><term>Hepatitis</term><term>Herpes virus</term><term>Host cells</term><term>Human immunodeficiency virus type</term><term>Indiana university</term><term>Infection</term><term>Iron content</term><term>Iron loading</term><term>Iron metabolism</term><term>Iron reduction therapy</term><term>Iron values</term><term>Iron withholding</term><term>Iron withholding defense system</term><term>Japanese encephalitis virus</term><term>Karupiah harris</term><term>Kupffer cells</term><term>Macrophage</term><term>Mild infections</term><term>Nitric</term><term>Nitric oxide</term><term>Oxidative stress</term><term>Oxide</term><term>Replication</term><term>Serum ferritin</term><term>Serum iron</term><term>Serum iron levels</term><term>Similar study</term><term>Smoker</term><term>Surface antigen</term><term>Thalassemic patients</term><term>Transcriptase activity</term><term>Transferrin</term><term>Transferrin iron saturation</term><term>Transfusion</term><term>Viral</term><term>Viral infections</term><term>Viral replication</term><term>Weinberg</term><term>Weinberg weinberg</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: A variety of laboratory and clinical investigations during the past 15 years have observed that one of the dangers of excessive iron is its ability to favor animal viral infections. The metal is essential for host cell synthesis of virions and can also impair defense cell function and increase oxidative stress. In both animal models and humans, viral infections cause upregulation of the iron withholding defense system. Factors that suppress the system enhance viral progression; factors that strengthen the system augment host defense. Procedures designed to reinforce the system are being developed and tested; some of these may become useful adjuncts in prevention and management of viral diseases.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><country name="États-Unis"><region name="Indiana"><name sortKey="Weinberg, E D" sort="Weinberg, E D" uniqKey="Weinberg E" first="E. D." last="Weinberg">E. D. Weinberg</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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